�Scientists at The University of Manchester have developed a new and fast method for making biological 'chips' - technology that could track to agile testing for serious diseases, fast detection of MRSA infections and rapid discovery of raw drugs.
Researchers working at the Manchester Interdisciplinary Biocentre (MIB) and The School of Chemistry experience unveiled a new technique for producing functional 'protein chips' in a paper in the Journal of the American Chemical Society (JACS), published online.
Protein chips - or 'protein arrays' as they are more commonly known - ar objects such as slides that have proteins attached to them and countenance important scientific data around the behaviour of proteins to be gathered.
Functional protein arrays could give scientists the ability to consort tests on tens of thousands of different proteins simultaneously, observing how they interact with cells, other proteins, DNA and drugs.
As proteins throne be situated and set precisely on a 'chip', it would be possible to scan large numbers of them at the same clock time but then isolate the data relating to case-by-case proteins.
These french-fried potatoes would allow for large amounts of data to be generated with the minimum use of materials - especially rare proteins that are but available in very small amounts.
The Manchester team of Dr Lu Shin Wong, Dr Jenny Thirlway and Prof Jason Micklefield say the expert challenges of attaching proteins in a reliable way have antecedently held gage the widespread application and development of protein chips.
Existing techniques for attaching proteins often results in them becoming fixed in random orientations, which can causal agency them to become damaged and inactive.
Current methods too require proteins to be purified offset - and this means that creating large and powerful protein arrays would be hugely costly in terms of time, men and money.
Now researchers at The University of Manchester say they have establish a reliable new means of attaching active proteins to a chip.
Biological chemists have engineered modified proteins with a special tag, which makes the protein attach to a control surface in a highly specified way and ensures it remains functional.
The attachment occurs in a single stair in precisely a few hours - unlike with existing techniques - and requires no prior chemical modification of the protein of involvement or extra chemical steps.
Prof Jason Micklefield from the School of Chemistry, said: "DNA french fries have revolutionised biological and medical scientific discipline. For many years scientists have tested to develop similar protein chips but technical difficulties associated with attaching big numbers of proteins to surfaces have prevented their widespread application.
"The method we have highly-developed could get profound applications in the diagnosis of disease, screening of new drugs and in the detection of bacteria, pollutants, toxins and other molecules."
Researchers from The University of Manchester ar currently working as contribution of a consortium of several universities on a �3.1 million project which is aiming to develop supposed 'nanoarrays'.
These would be much smaller than existing 'micro arrays' and would leave thousands more than protein samples to be placed on a single 'chip', reducing cost and vastly increasing the volume of data that could be at the same time collected.
This jut out, which involves the universities of Manchester, Sheffield, Nottingham and Glasgow, is being supported by Research Councils UK (RCUK), the umbrella body for academic research funding in the UK.
Source: Alex Waddington
University of Manchester
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Tuesday, 26 August 2008
Saturday, 16 August 2008
Download Estradasphere
 Artist: Estradasphere: mp3 download Genre(s): Indie Rock ROck: Alternative Discography:  Palace of Mirrors Year: 2006 Tracks: 13  Quadropus Year: 2003 Tracks: 8  Silent Elk of Yesterday Year: 2001 Tracks: 18  It's Understood Year: 2001 Tracks: 12  Buck Fever Year: 2001 Tracks: 16 Unmistakably derived from the genre-bending pubic region of data-based rockers Mr. Bungle and Secret Chiefs 3, Estradasphere respectfully lives up to the challenging musical aims of their wildly gifted mentors. Tim Harris, violin and trumpet, Dave Murray, drums, Jason Schimmel, guitar and banjo, bassist Tim Smolens, and John Wooley, sax, met in the late '90s at the U.C.-Santa Cruz school of music, where they divided up an interest in the tackiest aspects of pop culture and the to the highest degree inordinate forms of music. Their first record album, It's Understood, appeared with following to no commercial-grade fanfare in the leap of 2000 as the number one spillage on Mr. Bungle guitarist Trey Spruance's homespun label Mimicry Records. Their feverish ruffle of jazz, alloy, video recording game themes, and blue grass was eaten up by hard-core Mr. Bungle fans, merely went largely unnoticed elsewhere. With instrumentality resembling Bela Fleck and the Flecktones, Estradasphere doesn't ever call forth immediate sonic comparisons to Mr. Bungle, merely their manic, short-attention-span philosophy of writing apparently does. Drawing on influences all over the musical spectrum, a great deal inside the same birdcall, Estradasphere amply demonstrates the breadth of their technical musical talent on a song-by-song basis. Although their first album doesn't certify the conciseness of Mr. Bungle or Secret Chiefs 3, it stretches out as an telling musical landscape for such a young set of musicians. Accompanied onstage by a collecting of Bohemian artists, ranging from fire-breathers to book-readers, Estradasphere exudes an excess of vernal muscularity and creativity, which, with a decorous amount of packaging, could finally grant them a solid resistance following. |
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Thursday, 7 August 2008
Bernie Mac hospitalized in Chicago with pneumonia
CHICAGO �
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Bernie Mac is in a Chicago hospital with pneumonia.
His publiciser, Danica Smith, says in a statement that the 50-year-old comedian is responding well to treatment and should be released presently. He remained hospitalized Saturday.
Smith says the pneumonia isn't related to an inflammatory lung disease that Mac also has. That condition has been in remittance since 2005.
Mac is a Chicago native who lives in the southern suburbs. He made waves utmost month with off-color jokes during a Chicago fundraiser for Democratic presidential candidate Barack Obama.
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